Adrenal Reaction
Craftable

Your body creates excessive adrenaline when injured, boosting damage output significantly at low health.

POSITIVE

+weapon damage at low health (up to +50%)

NEGATIVE

-50 max HP

RECOMMENDED FOR

Bloodied CommandoBloodied Heavy GunnerMelee Berserker
Bird Bones
Craftable

Your bones become hollow and lightweight, improving agility but reducing physical strength.

POSITIVE

+4 Agility, slow falling

NEGATIVE

-4 Strength

RECOMMENDED FOR

Stealth RiflemanBloodied CommandoVATS Crit builds
Carnivore
Craftable

Your digestive system adapts to a meat-only diet, extracting more nutrients from animal products.

POSITIVE

Meat gives 2x benefits, no disease from meat

NEGATIVE

Cannot eat vegetables

RECOMMENDED FOR

All builds - QoL mutation
Chameleon
Craftable

Your skin can change its appearance to match the environment when stationary.

POSITIVE

Invisible while sneaking and stationary (unarmored)

NEGATIVE

Must be unarmored for effect

RECOMMENDED FOR

Stealth builds without armor
Eagle Eyes
Craftable

Your vision becomes incredibly sharp, allowing precise critical hits.

POSITIVE

+4 Perception, +25% critical damage

NEGATIVE

-4 Strength

RECOMMENDED FOR

VATS Crit CommandoStealth RiflemanPistol builds
Egg Head
Craftable

Your brain grows larger, increasing intelligence but straining your body.

POSITIVE

+6 Intelligence

NEGATIVE

-3 Strength, -3 Endurance

RECOMMENDED FOR

XP farming buildsCrafting builds
Electrically Charged
Craftable

Your body generates electrical charges that shock anyone who touches you.

POSITIVE

Chance to shock melee attackers

NEGATIVE

Small amount of damage to self

RECOMMENDED FOR

Melee TankClose Combat builds
Empath
Craftable

You share pain with your teammates, reducing their damage at the cost of your own safety.

POSITIVE

Teammates take -25% damage

NEGATIVE

You take +33% damage

RECOMMENDED FOR

Team SupportTank builds with Strange in Numbers
Grounded
Craftable

Your body becomes highly resistant to electrical damage but struggles to channel energy.

POSITIVE

+100 Energy Resistance

NEGATIVE

-50% energy weapon damage

RECOMMENDED FOR

Tank buildsNon-energy weapon builds
Healing Factor
Craftable

Your body heals incredibly fast but metabolizes chems before they can take effect.

POSITIVE

+300% HP regeneration out of combat

NEGATIVE

-55% chem effects

RECOMMENDED FOR

Full Health buildsNon-chem dependent builds
Herbivore
Craftable

Your digestive system adapts to a plant-only diet, extracting more nutrients from vegetables.

POSITIVE

Vegetables give 2x benefits, no disease from plants

NEGATIVE

Cannot eat meat

RECOMMENDED FOR

All builds - QoL mutation
Herd Mentality
Craftable

You thrive in groups but struggle when alone.

POSITIVE

+2 to all SPECIAL stats when grouped

NEGATIVE

-2 to all SPECIAL stats when solo

RECOMMENDED FOR

Team-focused buildsCasual 76 shared perk builds
Marsupial
Craftable

Your legs become incredibly powerful, allowing massive jumps and increased carry capacity.

POSITIVE

+20 carry weight, greatly increased jump height

NEGATIVE

-4 Intelligence

RECOMMENDED FOR

All builds - Essential QoL mutation
Plague Walker
Craftable

Diseases empower a toxic aura around you that damages nearby enemies.

POSITIVE

Poison aura that scales with your diseases

NEGATIVE

No positive effect without diseases

RECOMMENDED FOR

Disease-focused novelty builds
Scaly Skin
Craftable

Your skin hardens into protective scales, reducing incoming damage.

POSITIVE

+50 Damage and Energy Resistance

NEGATIVE

-50 AP

RECOMMENDED FOR

Tank buildsNon-VATS builds
Speed Demon
Craftable

Your metabolism speeds up dramatically, making you faster in all ways.

POSITIVE

+20% movement speed, +30% faster reload

NEGATIVE

+50% drain on hunger and thirst

RECOMMENDED FOR

All builds - Essential QoL mutation
Talons
Craftable

Your fingers grow into sharp claws, perfect for devastating unarmed attacks.

POSITIVE

+25% unarmed damage, chance to bleed

NEGATIVE

-4 Agility

RECOMMENDED FOR

Unarmed Melee builds
Twisted Muscles
Craftable

Your muscles twist and grow, increasing melee power but affecting gun handling.

POSITIVE

+25% melee damage, chance to cripple

NEGATIVE

-50% gun accuracy

RECOMMENDED FOR

Melee builds only
Unstable Isotope
Craftable

Your body emits unstable radiation that can harm attackers.

POSITIVE

Chance to irradiate melee attackers

NEGATIVE

Small amount of radiation damage to self

RECOMMENDED FOR

Bloodied buildsMelee Tank